Subgingival application of 0.5% Azithromycin gel as a local drug delivery system as an adjunct to scaling and root planing in controlled diabetic patients- An in vivo study

Introduction: A recent trend involving the use of local delivery systems to deliver chemotherapeutic agents implies improved periodontal health. As part this study, a locally delivered 0.5% azithromycin gel was evaluated for its clinical and microbiological efficacy in treating chronic periodontitis patients with controlled diabetes.
 Material Methods: The split-mouth study design used randomized control trial. included 50 sites from 25 who had pocket depths greater than 5 mm were diagnosed periodontitis. Two treatment groups randomly assigned: scaling root planing only (control group) or (test group). At selected sites, gingival index, probing depth, attachment level analyzed both at baseline, 6 weeks, 12 weeks.
 Result & observations: Both test parameters when compared baseline. depth 6.64±1.07 7.36±1.15 which decreased 4.84±0.59 4.32±0.98 respectively weeks. difference statistically significant p<0.001. Statistically levels between baseline results all categories significantly groups, while group showed improvement.
 Conclusion: It concluded that could be beneficial diabetes conjunction planing.
 Keywords: Local drug delivery, Periodontal disease, Diabetes, Azithromycin gel.